The REVEAL Study – Genomes to People

The Risk Evaluation and Education for Alzheimer’s Disease (REVEAL) Study, funded by NIH, was the first ever study to disclose APOE Alzheimer’s Disease risk to healthy patients and made important contributions to the scientific understanding of disclosing genetic risk for Alzheimer’s Disease.Through a series of multi-site randomized controlled clinical trials, REVEAL provided empirical data to address ethical, … Continued

Publications

2021

Disclosing APOE genotype to individuals at risk for Alzheimer’s disease

Roberts JS, Green RC

Alzheimer's Disease International Sep 2021

Using the Alzheimer’s Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer’s disease

Veitch DP, Weiner MW, Aisen PS, Beckett LA, DeCarli C, Green RC, Harvey D, Jack CR, Jagust W, Landau SM, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ, Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & Dementia: The Journal of the Alzheimer's Association Sep 2021

How will Aducanumab approval impact Alzheimer’s disease research?

Weiner MW, Aisen PS, Beckett LA, Green RC, Jagust William, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Mindt MR, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ and the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Journal of Prevention of Alzheimer's Disease Jul 2021

2020

Disclosing genetic risk of Alzheimer’s dementia to individuals with mild cognitive impairment

Christensen KD, Karlawish J, Roberts JS, Uhlmann WR, Harkins K, Wood EM, Obisesan TO, Le LQ, Cupples LA, Zoltick ES, Johnson MS, Bradbury MK, Waterston LB, Chen CA, Feldman S, Perry DL, Green RC

Alzheimer's & Dementia: Translational Research & Clinical Interventions Mar 2020

2018

Communication predictors of patient and companion satisfaction with Alzheimer’s genetic risk disclosure

Guan Y, Roter DL, Erby LH, Wolff JL, Gitlin LN, Roberts JS, Green RC, Christensen KD

Journal of Health Communication Oct 2018

The impact of genetic counselors’ use of facilitative strategies on cognitive and emotional processing of genetic risk disclosure for Alzheimer’s disease

Guan Y, Roter DL, Wolff JL, Gitlin LN, Christensen KD, Roberts JS, Green RC, Erby LH.

Patient Education and Counseling May 2018

2017

A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone

Christensen KD, Uhlmann WR, Roberts JS, Linnenbringer E, Whitehouse PJ, Royal CDM, Obisesan TO, Cupples LA, Butson MB, Fasaye GA, Hiraki S, Chen CA, Siebert U, Cook-Deegan R, Green RC.

Genetics in Medicine Jul 2017

Disclosing genetic risk of Alzheimer’s disease to cognitively impaired patients and visit companions: Findings from the REVEAL Study

Guan Y, Roter DL, Erby LH, Wolff JL, Gitlin LN, Roberts JS, Green RC, Christensen KD

Patient Education and Counseling May 2017

2016

Disclosing pleiotropic effects during genetic risk assessment for Alzheimer’s Disease: A randomized trial

Christensen KD, Roberts JS, Whitehouse PJ, Royal CDM, Obisesan TO, Cupples LA, Vernarelli JA, Bhatt DL, Linnenbringer E, Butson MB, Fasaye G-A, Uhlmann WR, Hiraki S, Cook-Deegan R, Green RC, for the REVEAL Study Group.

Annals of Internal Medicine Feb 2016

2015

A randomized non-inferiority trial of condensed protocols for genetic risk disclosure of Alzheimer’s disease

Green RC, Christensen KD, Cupples LA, Relkin NR, Whitehouse PJ, Royal CD, Obisesan TO, Cook-Deegan R, Linnenbringer E, Butson MB, Fasaye G, Levinson E, Roberts JS

Alzheimer's & Dementia Oct 2015

Development of a process to disclose amyloid imaging results to cognitively normal older adult research participants

Harkins K, Sankar P, Sperlin R, Grill JD, Green RC, Johnson KA, Healy M, Karlawish J

Alzheimer's Research & Therapy Sep 2015

Associations between self-referral and health behavior responses to genetic risk information

Christensen KD, Roberts JS, Zikmund-Fisher BJ, Kardia SLR, McBride CM, Linnenbringer E, Green RC.

Genome Medicine Jan 2015

Factors affecting recall of different types of personal genetic information about Alzheimer’s disease risk: The REVEAL Study

Besser AG, Sanderson SC, Roberts JS, Chen CA, Christensen KD, Lautenbach DM, Cupples LA, Green RC.

Public Health Genomics Jan 2015

2014

APOE ε4, rated life experiences, and affect among centenarians

Martin P, Jazwinski SM, Davey A, Green RC, Macdonald M, Margrett JA, Siegler IC, Arnold J, Woodard JL, Johnson MA, Kim S, Dai J, Li L, Batzer MA, Poon LW

Aging and Mental Health Mar 2014

Minding the aging brain: Are we ready for personalized medicine?

Karlawish J, Green RC.

American Journal of Psychiatry Feb 2014

2013

Distinct communication patterns during genetic counseling for late-onset Alzheimer’s risk assessment

Lerner B, Roberts JS, Shwartz M, Roter D, Green RC, Clark JA.

Patient Education and Counseling Nov 2013

Communicating genetic risk information for common disorders in the era of genomic medicine

Lautenbach DM, Christensen KD, Sparks JA, Green RC

Annual Reviews in Genomics and Human Genetics Aug 2013

2012

Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease

Roberts JS, Chen CA, Uhlmann WR, Green RC.

Genetics in Medicine Apr 2012

The genetics of Alzheimer’s disease

Schu MC, Sherva R, Farrer LA, Green RC.

Advances in Biological Psychiatry Jan 2012

2011

Willingness to pay for genetic testing for Alzheimer’s disease: a measure of personal utility

Kopits IM, Chen C, Roberts JS, Uhlmann W, Green RC

Genetic Testing and Molecular Biomarkers Dec 2011

A comprehensive genetic association study of Alzheimer disease in African Americans

Logue MW, Schu M, Vardarajan BN, Buros J, Green RC, Go RC, Griffith P, Obisesan TO, Shatz R, Borenstein A, Cupples LA, Lunetta KL, Fallin MD, Baldwin CT, Farrer LA

Archives of Neurology Dec 2011

Using Alzheimer’s disease as a model for genetic risk disclosure: Implications for personal genomics

Roberts JS, Christensen KD, Green RC.

Clinical Genetics Jul 2011

Differences between African American and white research volunteers in their attitudes, beliefs and knowledge regarding genetic testing for Alzheimer’s disease

Akinleye D, Roberts JS, Royal CDM, Linnenbringer E, Obisesan T, Gasaye, G-A, Green RC.

Journal of Genetic Counseling Jun 2011

Changes to perceptions of the pros and cons of genetic susceptibility testing after APOE genotyping for Alzheimer disease risk

Christensen K, Roberts JS, Uhlmann WR, Green RC.

Genetics in Medicine Jan 2011

2010

The role of disease perceptions and results sharing on psychological adaptation in genetic susceptibility testing: The REVEAL Study

Ashida S, Koehly L, Roberts JS, Chen C, Hiraki S, Green RC.

European Journal of Human Genetics Jul 2010

Effect of Alzheimer disease genetic risk disclosure on dietary supplement use

Vernarelli JA, Roberts JS, Chen CA, Cupples LA, Green RC.

The American Journal of Clinical Nutrition Mar 2010

“I know what you told me, but this is what I think”: Perceived risk of Alzheimer’s disease among individuals who accurately recall their genetics-based risk estimate

Linnenbringer E, Roberts JS, Hiraki S, Cupples LA, Green RC.

Genetics in Medicine Feb 2010

The authors reply to letter to the editor: Disclosure of the genetic risk of Alzheimer’s disease

Roberts JS, Cupples LA, Green RC.

New England Journal of Medicine Jan 2010

Genetic testing for Alzheimer’s and long-term care insurance

Taylor DH, Cood-Deegan R, Hiraki S, Roberts JS, Blazer DG, Green RC.

Health Affairs Jan 2010

2009

Disclosing the disclosure: Factors associated with communicating the results of genetic susceptibility testing for Alzheimer’s disease

Ashida S, Koehly LM, Roberts JS, Chen C, Hiraki S, Green RC.

Journal of Health Communication Dec 2009

Disclosure of APOE genotype for risk of Alzheimer’s disease

Green RC, Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Brown T, Eckert SL, Butson M, Sadovnick AD, Quaid KA, Chen C, Cook-Deegan R, Farrer LA, for the REVEAL Study Group.

New England Journal of Medicine Jul 2009

A new scale measuring psychologic impact of genetic susceptibility testing for Alzheimer disease

Chung WW, Chen CA, Cupples LA, Roberts JS, Hiraki SC, Nair AK, Green RC, Stern RA.

Alzheimer's Disease and Associated Disorders Jan 2009

2008

Comparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer’s disease

Cassidy MR, Roberts JS, Bird TD, Steinbart EJ, Cupples LA, Chen CA, Linnenbringer E, Green RC.

Alzheimer's and Dementia Nov 2008

Perceptions of familial risk in those seeking a genetic risk assessment for Alzheimer’s disease

Hiraki S, Chen CA, Roberts JS, Cupples LA, Green RC.

Journal of Genetic Counseling Oct 2008

Explaining behavior change after genetic testing: The problem of collinearity between test results and risk estimates

Fanshawe TR, Prevost AT, Roberts JS, Green RC, Armstrong D, Marteau TM.

Genetic Testing Jul 2008

Incorporating ethnicity into genetic risk assessment for Alzheimer’s disease: The REVEAL study experience

Christensen KD, Roberts JS, Royal CDM, Fasaye G, Obisesan T, Cupples LA, Whitehouse PJ, Butson MB, Linnenbringer E, Relkin NR, Farrer L, Cook-Deegan R, Green RC.

Genetics in Medicine Mar 2008

Health behavior changes after genetic risk assessment for Alzheimer disease: The REVEAL study

Chao S, Roberts JS, Marteau TM, Silliman R, Cupples LA, Green RC.

Alzheimer's Disease and Associated Disorders Jan 2008

2006

Recall of disclosed Apolipoprotein E genotype and lifetime risk estimate for Alzheimer’s disease: The REVEAL Study

Eckert SL, Katzen H, Roberts JS, Barber M, Ravdin LD, Relkin NR, Whitehouse PJ, Green RC.

Genetics in Medicine Dec 2006

Genetic susceptibility testing for Alzheimer disease: Motivation to obtain information and control as precursors to coping with increased risk

Gooding HC, Linnebringer EL, Burack J, Roberts JS, Green RC, Biesecker BB.

Patient Education and Counseling Jul 2006

Areas of intervention for genetic counseling of dementia: Cross-cultural comparison between Italians and Americans

Binetti G, Benussi L, Roberts S, Villa A, Pasqualetti P, Sheu C-F, Gigola L, Lussignoli G, Dal Forno G, Barbiero L, Corbellini, Green RC, Rossini PM, Ghidoni R.

Patient Education and Counseling Jul 2006

2005

Genetic risk assessment for adult children of people with Alzheimer’s disease

Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Green RC.

Journal of Geriatric Psychiatric Neurology Dec 2005

Predictive genetic testing for Alzheimer’s disease: Impact upon perceived risk of Alzheimer’s disease

Marteau T, Roberts JS, LaRusse SA, Green RC.

Risk Analysis Apr 2005

Genetic testing for Alzheimer’s disease and its impact on insurance purchasing behavior

Zick CD, Matthews C, Roberts JS, Cook-Deegan R, Pokorski RJ, Green RC.

Health Affairs Mar 2005

Diagnosis and Management of Alzheimer’s Disease and Other Dementias

Book

Robert C. Green

Jan 2005

Genetic susceptibility for Alzheimer’s disease: Why did adult offspring seek testing?

Hurley AC, Harvey R, Roberts JS, Wilson-Chase C, Lloyd S, Prest J, Lock M, Horvath KJ, Green RC.

American Journal of Alzheimer's Disease and Other Dementias Jan 2005

Genetic susceptibility testing versus family history-based risk assessment: Impact on perceived risk of Alzheimers disease

LaRusse SA, Roberts JS, Marteau T, Katzen H, Linnenbringer E, Barber M, Whitehouse P, Quaid K, Brown T, Green RC, Relkin N.

Genetics in Medicine Jan 2005

2004

Who seeks genetic susceptibility testing for Alzheimer’s disease? Findings from a multisite, randomized clinical trial

Roberts JS, Barber M, Brown T, Cupples LA, Farrer L, LaRusse SA, Post S, Quaid K, Ravdin L, Relkin N, Sadovnick D, Whitehouse P, Woodard J, Green RC.

Genetics in Medicine Jul 2004

Estimating risk curves for first-degree relatives of patients with Alzheimer’s disease: The REVEAL study

Cupples LA, Farrer LA, Sadovnick D, Relkin N, Whitehouse P, Green RC.

Genetics in Medicine Jul 2004

2003

Differences between African Americans and whites in their attitudes toward genetic testing for Alzheimer’s disease

Hipps YG, Roberts JS, Green RC.

Genetic Testing Jul 2003

Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease

Roberts JS, LaRusse SA, Katzen H, Whitehouse PJ, Barber M, Post SG, Relkin N, Quaid K, Pietrzak RH, Cupples LA, Farrer LA, Brown T, Green RC.

Alzheimer's Disease and Associated Disorders Apr 2003

Differences between African Americans and whites in their perceptions of Alzheimer disease

Roberts JS, Connell CM, Cisewski D, Hipps YG, Demissie S, Green RC.

Alzheimer's Disease and Associated Disorders Jan 2003

2002

1998

Commentary on: Utility of the Apolipoprotein E genotype in the diagnosis of Alzheimer’s disease by Mayeux et al in NEJM

Green RC, Stewart WF.

Neurology Network Jan 1998

1997

Risk of Alzheimer disease is associated with parental age among apolipoprotein E4 heterozygotes

Farrer LA, Cupples LA, Kukull WA, Volicer L, Wells JM, Kurz A, Green RC, Chui H, Duara R, Auerbach SA, Larson E, Lautenschlager N, Wolf PA, D'Agostino R, Ordovas J, Schaefer E, Growdon J, Haines J.

Alzheimer's Research Jun 1997