The PGen Study

The rapid identification of genetic risk factors for common, complex diseases poses great opportunities and challenges for public health. Genetic information is increasingly being utilized as part of commercial efforts, including personal genomic testing, to provide consumers with genetic risk information related to common diseases. Few empirical data have been gathered to understand the characteristics … Continued

Publications

2017

Racial minority group interest in direct-to-consumer genetic testing: Findings from the PGen study

Landry L, Nielsen DE, Carere DA, Roberts JS, Green RC.

Journal of Community Genetics Sep 2017  

Consumer perspectives on access to direct-to-consumer genetic testing: Role of demographic factors and the testing experience

Gollust SE, Gray SW, Carere DA, Koenig BA, Lehmann LS, McGuire AL, Sharp RR, Spector-Bagdady K, Wang N, Green RC, Roberts JS

Milbank Quarterly Jun 2017  

Utilization of genetic counseling after direct-to-consumer genetic testing: Findings from the Impact of Personal Genomics (PGen) Study

Koeller DR, Uhlmann WR, Carere DA, Green RC, Roberts JS

Journal of Genetic Counseling May 2017  

Diet and exercise changes following direct-to-consumer personal genomic testing

Nielsen DE, Carere DA, Wang C, Roberts JS, Green RC

BMC Medical Genomics May 2017  

Personal genomic testing for cancer risk: Results from the impact of personal genomics (PGen) study

Gray SW, Gollust SE, Carere DA, Chen CA, Cronin A, Kalia SS, Rana HQ, Ruffin MT IV, Wang C, Roberts JS, Green RC

Journal of Clinical Oncology Feb 2017  

Direct-to-consumer genetic testing: User motivations, decision making, and perceived utility of results

Roberts JS, Gornick MC, Carere AD, Uhlmann WR, Ruffin MT, and Green RC.

Public Health Genomics Jan 2017  

2016

Prescription medication changes following direct-to-consumer personal genomic testing

Carere DA, VanderWeele T, Vassy JL, van der Wouden C, Roberts JS, Kraft P, Green RC.

Genetics in Medicine Sep 2016  

The impact of personal genomics on risk perceptions and medical decision-making

Krieger JL, Murray F, Roberts JS, Green RC

Nature Biotechnology Sep 2016  

Implications of personal genomic testing for health behaviors: The case of smoking

Olfson E, Hartz S, Carere D, Green RC, Roberts JS, Bierut L.

Nicotine & Tobacco Research Jul 2016  

Consumer perceptions of interactions with primary care providers after direct-to-consumer personal genomic testing

van der Wouden CH, Carere DA, Maitland-van der Zee AH, Ruffin MT, Roberts JS, Green RC for the PGen Study Group.

Annals of Internal Medicine Apr 2016  

Consumers report lower confidence in their genetics knowledge following direct-to-consumer personal genomic testing

Carere DA, Kraft P, Kaphingst KA, Roberts JS, Green RC for the PGen Study Group.

Genetics in Medicine Mar 2016  

Adopting genetics: Motivations and outcomes of personal genomic testing in adult adoptees

Baptista NM, Christensen KD, Carere DA, Broadley SA, Roberts JS, Green RC.

Genetics in Medicine Jan 2016  

2015

The impact of direct-to-consumer personal genomic testing on perceived risk of breast, prostate, colorectal, and lung cancer: Findings from the PGen study

Carere DA, VanderWeele T, Moreno TA, Mountain JL, Roberts JS, Kraft P, Green RC.

BMC Medical Genomics Oct 2015  

Explaining, not just predicting, drives interest in personal genomics

Meisel SF, Carere DA, Wardle J, Kalia SS, Moreno TA, Mountain JL, Roberts JS, Green RC.

Genome Medicine Aug 2015  

How well do customers of direct-to-consumer personal genomic testing services comprehend genetic test results? Findings from the Impact of Personal Genomics Study

Ostergren JE, Gornick MC, Carere DA, Kalia SS, Uhlmann WR, Ruffin MT, Mountain JL, Green RC, Roberts JS

Public Health Genomics Jun 2015  

2014

Design, methods, and participant characteristics of the Impact of Personal Genomics (PGen) Study, a prospective cohort study of personal genomics testing customers

Carere DA, Couper MP, Crawford SD, Duggan JR, Moreno TA, Mountain JL, Roberts JS, Green RC.

Genome Medicine Dec 2014  

Regulation: The FDA is overcautious on consumer genomics

Green RC, Farahany NA.

Nature Jan 2014  

2013

Variations in predicted risks in personal genome testing for common complex diseases

Kalf RRJ, Mihaescu R, Kundu S, de Knijff P, Green RC, Janssens ACJW.

Genetics in Medicine Jun 2013  

Attitudes about regulation among direct-to-consumer genetic testing customers

Bollinger JM, Green RC, Kaufman D.

Genetic Testing and Molecular Biomarkers Apr 2013  

2012

Navigating a research partnership between academia and industry to assess the impact of personalized genetic testing

Lehmann LS, Kaufman DJ, Sharp RR, Moreno TA, Mountain JL, Roberts S, Green RC.

Genetics in Medicine Jan 2012  

2011

Direct-to-consumer genetic testing: Reliable or risky?

Spencer DH, Lockwood C, Topol E, Evans JP, Green RC, Mansfield E, Tezak.

Clinical Chemistry Sep 2011  

The future of direct-to-consumer clinical genetic tests

Frueh FW, Greely HT, Green RC, Hogarth S, Siegel S.

Nature Reviews Genetics Jun 2011  

2010

Health care referrals from direct-to-consumer genetic testing

Giovanni M, Fickie M, Lehmann L, Green RC, Meckley L, Veenstra D, Murray M.

Genetic Testing and Molecular Biomarkers Oct 2010  

2009

Direct to consumer genetic testing: Avoiding a culture war

Evans JP, Green RC.

Genetics in Medicine Jul 2009  

Direct-to-consumer genetic testing: What’s the prognosis?

Lerner-Ellis J, Ellis D, Green RC.

GeneWatch Jan 2009