Does genome sequencing increase downstream medical costs?

Brigham Women's Hospital |
March 2018

“Whole genome sequencing is coming of age, but there’s fear that with these advancements will come rocketing health care costs,” said lead author Kurt Christensen, MPH, PhD, an instructor of medicine in the Division of Genetics at BWH. “Our pilot study is the first to provide insights into the cost of integrating whole genome sequencing … Continued

Study of clinical genome sequencing in the active-duty military begins

Brigham Women's Hospital |
October 2017

Up to 75 active-duty U.S. Air Force service members will now have the first opportunity to incorporate whole exome sequencing (WES) into their routine clinical care through a new two-year research partnership between the Air Force Personalized Medicine Program, Air Force Medical Genetics Center and several academic institutions, including Brigham Women’s Hospital, Broad Institute, Harvard … Continued

Are you ready to explore your baby’s genome?

Brigham Women's Hospital |
January 2017

“Simply putting together all the pieces to design these complicated research projects is an ambitious undertaking. But it is essential that we find ways to rigorously measure the clinical utility of new technologies so that we can apply them responsibly, and that is the focus of the BabySeq Project, and of the other NSIGHT projects.”

Studies probe value and impact of direct-to-consumer genetic testing

Brigham Women's Hospital |
December 2016

Despite being on the market for nearly a decade, direct-to-consumer (DTC) genetic testing continues to be controversial among experts and raises concerns among health care providers and regulatory agencies. The NIH-funded “Impact of Personal Genomics (PGen) Study” addresses these concerns by empirically measuring the perceptions and tracking the behaviors of individuals who have received DTC … Continued

Will unanticipated genetic mutations lead to subsequent disease?

Brigham Women's Hospital |
November 2016

A study published in the journal Science Translational Medicine is the first to show that mutations in certain cancer and cardiovascular genes put individuals at an increased risk for dominantly inherited, actionable conditions, regardless of family medical history. The study, carried out in two separate populations of African-Americans and European-Americans, finds that individuals carrying these … Continued

Disclosure of incidental genetic findings can have positive impact for patients

Brigham Women's Hospital |
January 2016

A new study has found that providing unanticipated information about risk of coronary artery disease during a genetic risk assessment for Alzheimer’s disease helped some participants cope with their results, and also motivated participants to make changes to their health behaviors. The results of the randomized controlled study are published online in the journal Annals of … Continued

Genome sequencing for newborns: What do new parents think?

Brigham Women's Hospital |
December 2014

A study published this week in Genetics in Medicine is the first to explore new parents’ attitudes toward newborn genomic testing. The findings suggest that if newborn genomic testing becomes available, there would be robust interest among new parents, regardless of their demographic background.

Genomic technology enters the mainstream practice of medicine

Brigham Women's Hospital |
June 2014

A review article titled, “Diagnostic Clinical Genome and Exome Sequencing” published in the The New England Journal of Medicine (NEJM), summarizes the technologies underlying CGES and offers insights for how clinicians should order such testing, interpret the results, and communicate the results to their patients.

Brigham and Women’s Hospital awarded $6-million to study genome sequencing in newborns

Brigham Women's Hospital |
September 2013

“This first-of-its-kind study will accelerate the use of genomics in clinical pediatric medicine by creating and safely testing novel methods for integrating sequencing into the care of newborns. We will implement and study a futuristic goal: that genomic information examined shortly after birth can serve as a resource throughout infancy and childhood to inform clinical … Continued

For the first time, recommendations offer guidance about incidental findings in clinical genomic sequencing

Brigham Women's Hospital |
March 2013

In a highly anticipated report, landmark recommendations on the handling of incidental findings in clinical genome and exome sequencing are being issued from the American College of Medical Genetics and Genomics (ACMG). A report of the recommendations, led by Dr. Robert Green, MD, MPH, outlines for the first time a minimum list of genetic conditions, … Continued

Research gets real – public votes determine winner of $100,000 research prize

Brigham Women's Hospital |
November 2012

Robert Green, MD, MPH, has been named the winner of the $100,000 BRIght Futures Prize, after a unique competition in which nearly 6,500 online votes from people across the globe determined the winning project. Dr. Green’s project, which will explore the genome sequencing of newborns, emerged as the winner after six weeks of public voting.